Exogenous Progesterone Produces Significant Histomorphological Changes in the Lungs of Experimental BALB/c Mice

Background: Progesterone is used in combined oral contraceptive pills and also has its effect on the respective receptors which are responsible for sexual development. Bronchial asthma emerges to be a major health issue Pakistan with estimated prevalence about 5% of total population. Epidemiological studies highlight that one considerable risk factor morbidity mortality inflammatory lung diseases female gender. This suggests sex-related hormones might play an imperative role disease progression. Understanding biological sex regulating airway inflammation crucial given rising chronic among women worldwide. Aim: To determine progesterone lungs adult male mice by assessing comparing histological parameters e.g. bronchiolar smooth muscle size peri-bronchial lymphocytic infiltration. Study Design: Randomized control trial Place Duration Study: Department Physiology, Islamabad Medical & Dental College collaboration National Institute Health from 1st October 2018 31st July 2019. Methodology: Sixty BALB/c were divided into 2 groups each group comprised 30 mice. Group I (control group) received only distilled water (norethisterone BP mixed distal according body weight respectively 60 days. Results: In response progesterone, 30% had nil, 40% mild, 26.7% who showed moderate while severe PBLI was observed 3.3% Different frequencies Bronchiolar Smooth Muscle Hyperplasia when compared Control group. Mild hyperplasia produced BP) Conclusion: hormone modulates processes producing pulmonary responses leading causes muscles. Keywords: Progesterone, Asthma, muscle, Peri-bronchial Infiltration,